Selected Publications

2020

Clinical spectrum of KCNA1 mutations: new insights into episodic ataxia and epilepsy comorbidity
Paulhus K, Ammerman L, Glasscock E
International Journal of Molecular Sciences 2020, 21:2802


Neuron-specific Kv1.1 deficiency is sufficient to cause epilepsy, premature death and cardiorespiratory dysregulation

Trosclair K, Dhaibar HA, Gautier NM, Mishra V, Glasscock E
Neurobiology of Disease 2020, 137:104759


2019

Kv1.1 channel subunits in the control of neurocardiac function
Glasscock E.
Channels 2019, 13:299-307


Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: implications for sudden unexpected death in epilepsy
Dhaibar H, Gautier NM, Chernyshev OY, Dominic P, Glasscock E
Neurobiology of Disease 2019, 127:502-511

Genetic ablation or pharmacological inhibition of Kv1.1 potassium channel subunits impairs atrial repolarization in mice
Si M, Trosclair K, Hamilton KA, Glasscock E
American Journal of Physiology- Cell Physiology 2019, 316:C154-C161


2018

Simultaneous video-EEG-ECG monitoring to identify neurocardiac dysfunction in mouse models of epilepsy 
*Mishra V, *Gautier NM, Glasscock E
Journal of Visualized Experiments 2018, 131: e57300

Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy 
Vanhoof-Villalba SL, Gautier NM, Mishra V, Glasscock E
Epilepsia 2018, 59:358-368


2017

Scn2a deletion improves survival and brain-heart dynamics in the Kcna1-null mouse model of sudden unexpected death in epilepsy (SUDEP).
Mishra V, Karumuri BK, Gautier NM, Liu R, Hutson TN, Vanhoof-Villalba SL, Vlachos I, Iasemidis L, Glasscock E.
Human Molecular Genetics 2017, 26:2091-2103
*article highlighted in Epilepsy Currents 2017, 17:306-310 


2016

Severe respiratory changes at end stage in a FUS-induced disease state in adult rats
Jackson KL, Dhaibar HA, Dayton RD, Cananzi SG, Mayhan WG, Glasscock E, Klein RL
BMC Neuroscience 2016, 17:69

Gradient index microlens implanted in prefrontal cortex of mouse does not affect behavioral test performance over time
Lee S, Holly K, Voziyanov V, Villalba S, Grigsby H, Glasscock E, Vlachos I, Murray T
PLoS One 2016, 11: e0146533


2015

Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation
Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou X-B, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XHT
Basic Research in Cardiology 2015, 110: 505

Spontaneous seizures in Kcna1-null mice lacking voltage-gated Kv1.1 channels activate Fos expression in select limbic circuits
Gautier N, Glasscock E
Journal of Neurochemistry 2015, 135: 157-164


2014

Genomic biomarkers of SUDEP in brain and heart
Glasscock E
Epilepsy & Behavior 2014, 38: 172-179
*article highlighted by Neurology Advisor


Pre-2013

Transcompartmental reversal of single fiber hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels
Glasscock E, Qian J, Kole MJ, Noebels JL
The Journal of Physiology 2012, 590: 3913-26

Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy
Glasscock E, Yoo J, Chen TT, Klassen TL, Noebels JL
The Journal of Neuroscience 2010, 30: 5167-5175
*article highlighted as Editors’ Choice in the journal Science Translational Medicine; feature “This Week in The Journal” article for the Neurobiology of Disease section of the Journal of Neuroscience

Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death
Goldman AM, Glasscock E, Yoo J, Chen TT, Klassen TL, Noebels JL
Science Translational Medicine 2009, 1: 2ra6

When a disease gene is not really a disease gene
Glasscock E, Noebels JL
Future Neurology 2008, 3: 103-106

Masking epilepsy by combining two epilepsy genes
Glasscock E, Qian J, Yoo JW, Noebels JL
Nature Neuroscience 2007, 10: 1554-1558
*article highlighted by Faculty of 1000

The mei-P26 gene encodes a RING finger B-box coiled-coil-NHL protein that regulates seizure susceptibility in Drosophilia
Glasscock E, Singhania A, Tanouye MA
Genetics 2005, 170: 1677-1689

Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypes
Glasscock E, Tanouye MA
Genetics 2005, 169: 2137-2149

 .